Our Facilities

Carlinville Family Practice
15574 Rt. 108 Carlinville, IL 62626
Phone (217) 854-4319
Fax (217) 854-2765
Open Monday - Friday
8:00 - 4:30

Gillespie Family Practice
715 W. Broadway
Gillespie, IL 62033
Phone (217) 839-4491
Fax (217) 839-2689
Open Monday - Friday
8:00 - 4:30
Saturday - 8:00 - Noon

Mt. Olive Family Practice
115 N. Poplar, Mt. Olive, IL 62069
Phone (217) 999-4751
Fax (217) 999-2317
Open Monday, Tuesday, Wednesday, Friday
8:00 - 4:30
Closed Thursday


The Macoupin Research Group’s mission is to provide patients with access to innovative treatments in a manner that protects human subjects and provides quality data to assess the risks and benefits of the specific treatment under investigation. Toward that end, we are dedicated to performing the highest quality clinical research and are committed to upholding the following core values:
  • Beneficence – Risk is minimized and proportional to anticipated benefit
  • Justice – Benefits and burdens are distributed fairly among different groups
  • Respect of Persons - Maintenance of privacy and confidentiality as well as full informed consent
  • Excellence and accuracy in subject selection and data collection
  • Honesty and integrity in all activities

Macoupin Family Practice Centers, LLP is a community-based, private practice group that provides primary care services for patients of all ages. The practice treats up to 125 patients each day and maintains an active primary care base of approximately 20,000 patients.

Providers: 3 physicians and 4 mid-level providers

Ancillary Services:

  • Bone Densitometry
  • In Home Sleep Study
  • Immunizations
  • Electrocardiograms
  • Simple fracture Treatment
  • Dressing Changes
  • Cryosurgery
  • Pulmonary Function Testing
  • Holter Monitoring
  • Laboratory (CAP & CLIA Certified)
  • Clinical Research
  • Physical Therapy
Patient Visits: over 44,000 patient encounters per year

Clinical Research

All clinical research activities conducted by Macoupin Family Practice providers are centrally coordinated and managed by highly trained research staff within the Macoupin Research Group (MRG). The MRG consists of a Principal Investigator, 2 Sub-Investigators and a Clinical Research Coordinator. The MRG staff have extensive experience conducting Phase III-IV Clinical Trials and are trained in ICH/GCP guidelines.

Trial Experience: 14+ trials conducted to date

Last FDA Audit: n/a

Research Staff:

Principal Investigator – Bruce Weber, M.D.
Sub-Investigators – Jason Manthei, PA-C
Jaclyn Hake, PA-C
Clinical Research Coordinator – Jennifer Swan, B.S.


Macoupin Research Group
715 W. Broadway Gillespie, IL 62033
Phone : 217-839-4491
Fax: 217-839-2689

MRG Standard Operating Procedures:
  • Standard Operating Procedures For SOPs
  • Adverse Event Reporting Procedures
  • Clinical Study Operations
  • Handling Clinical Trial Test Article
  • Communication Documentation
  • Coordinator Selection, Qualifications, Responsibilities and Training
  • Data Management
  • Informed Consent
  • Investigator Agreements With Sponsors/CROs
  • Investigator and Sub-Investigator Selection, Qualifications, Responsibilities and Training
  • Institutional Review Board Approval and Operations For Clinical Studies
  • Pre-Study Requirements
  • Protocol Handling, Review of Feasibility, and Approval
  • Quality Control
  • Subject Recruitment Methods
  • Regulatory Documentation/Essential Documents
  • Sponsor Interactions
  • Study Close-Out Activities
  • Study Confidentiality
  • Federal Food And Drug Administration (FDA) Audits
  • Handling Allegations of Misconduct and Fraud
  • Disaster Recovery Planning

Research Facilities

Gillespie Family Practice Center
715 W. Broadway
Gillespie, IL 62033
Phone: 217.839.4491
Fax: 217.839.2689

Located 60 minutes east of the St. Louis International Airport, our main clinic is a 6,000 square foot facility with nine exam rooms, a well-equipped laboratory for specimen processing, a secured investigational drug storage facility, specimen refrigerators, a -20o freezer for lab sample storage, dry ice processing, a state-of-the-art computer network with electronic medical records, a dedicated space for study coordinators and monitoring visits, fax access, copier access, high-speed internet, and ample space for study material.

Additional Facilities

To better serve our patient base, the Macoupin Research Group also has another 3,000 square foot facility, located twelve miles from our main facility:

Carlinville Family Practice Center
15574 Rt. 108
Carlinville, IL 62626
Phone: 217.854.4319
Fax: 217.854.2765

The Macoupin Research Group also has a smaller satellite office located at:

Mt. Olive Family Practice Center
115 North Poplar
Mt. Olive, IL 62069
Phone: 217.999.4751
Fax: 217.999.2317

Our Research Staff

 Bruce F. Weber, M.D., FAAFP
  • Principal Investigator
  • Geriatric Medicine Certified
  • Certified Clinical Densitometrist, ISCD
  • Diplomat, American Board of Family Practice
  • American Medical Association
  • American Academy of Family Physicians
  • Illinois Academy of Family Physicians

Jason K. Manthei, PA-C

  • Sub-Investigator
  • American Academy of Physician Assistants
  • Illinois Academy of Physician Assistants

Mary Amanda Pittman, FNP-C

  • Sub-Investigator
  • American Academy of Nurse Practitioners

Jennifer A. Swan, B.S.

  • Clinical Research Coordinator
  • FOX Commercial IRB Board Member
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